Article
Genetic variants of the HLA-G/LILRB1 ligand-receptor axis in donors or recipients are prognostic covariates for rejection after living kidney transplantation.
Frontiers in immunology - 1 Jan 2025
Hölzenbein Julian, Schramm Sabine, Heinemann Falko M, Heinold Andreas, Gäckler Anja, Reinold Johanna, Wilde Benjamin, Busch Yannik, Gruenen Nina, Peter Wolfgang, Horn Peter Alexander, Witzke Oliver, Rohn Hana, Rebmann Vera
Abstract excerpt
Background: HLA-G is a non-classical HLA class I molecule that promotes transplant tolerance. It engages the inhibitory receptor LILRB1 on immune effector cells, suppressing cytotoxic responses and inflammation, while promoting tolerogenic and regulatory immune phenotypes. Polymorphisms in the HLA-G 3' untranslated region (3'UTR) modulate HLA-G expression levels, and LILRB1 promoter variants influence receptor...
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