Article

Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 locus mismatches associated with long-term renal transplant survival

2022-12-22

Abstract excerpt

<h4>Background</h4> Long-term kidney allograft survival remains suboptimal. Emerging evidence indicates donor-recipient (D-R) mismatches outside of human leukocyte antigens (HLA) contribute to graft survival but mechanisms remain unclear, specifically for those mismatches within intronic regions. <h4>Methods</h4> We analyzed genome-wide SNP data of D-R pairs from two well-phenotyped kidney transplant cohorts (me...

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Literature Corpus work: 54fb4002-fa79-50c9-ab24-05b05f9c9be1
DOI: 10.1101/2022.12.21.521481

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