Article
HLA-G 3' untranslated region gene variants are promising prognostic factors for BK polyomavirus replication and acute rejection after living-donor kidney transplant.
Human immunology - 1 Apr 2020
Rohn Hana, Schwich Esther, Tomoya Michita Rafael, Schramm Sabine, Dolff Sebastian, Gäckler Anja, Korth Johannes, Heinemann Falko M, Wilde Benjamin, Trilling Mirko, Horn Peter A, Kribben Andreas, Witzke Oliver, Rebmann Vera
Abstract excerpt
The immunosuppressive non-classical human leukocyte antigen-G (HLA-G) promotes transplant tolerance as well as viral immune escape. HLA-G expression is associated with regulatory elements targeting certain single nucleotide polymorphisms (SNPs) in the HLA-G 3' untranslated region (UTR). Thus, we evaluated the impact of HLA-G 3'UTR polymorphisms as surrogate markers for BK polyomavirus (BKPyV) replication or...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.