DYRK1A-haploinsufficiency in mice causes autistic-like features and febrile seizures.

doi:10.1016/j.nbd.2017.12.003

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Article

DYRK1A-haploinsufficiency in mice causes autistic-like features and febrile seizures.

Neurobiology of disease - 1 Feb 2018

Raveau Matthieu, Shimohata Atsushi, Amano Kenji, Miyamoto Hiroyuki, Yamakawa Kazuhiro

Abstract excerpt

Mutations and copy number variants affecting DYRK1A gene encoding the dual-specificity tyrosine phosphorylation-regulated kinase 1A are among the most frequent genetic causes of neurodevelopmental disorders including autism spectrum disorder (ASD) associated with microcephaly, febrile seizures and severe speech acquisition delay. Here we developed a mouse model harboring a frame-shift mutation in Dyrk1a resulting...

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Identifiers

PMID: 29223763
DOI: 10.1016/j.nbd.2017.12.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.