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Article

Rs12516 A allele elevates the risk of colorectal cancer via functional CeRNA network of BDNF-AS, miR-4704-5p and BRCA1.

BMC cancer - 19 Jan 2026

Liu Daxu, Fan Zhijun, Zhang Teng, Li Xiaoxia, Ming Cui, Wu Jiahang, Lu Xiaobo, Sun Deyu

Abstract excerpt

BACKGROUND: DNA double-strand break repair has emerged as a vital pathway to repair DNA damage seriously related to the risk of colorectal cancer (CRC). METHODS: To explore valid susceptible biomarkers of CRC via investigating the association of single nucleotide polymorphisms in DSBR genes with CRC risk, seven polymorphisms located in 3'-untranslated regions of DSBR genes including RAD51 rs11852786, RAD51B...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41555274
DOI: 10.1186/s12885-025-14692-x
PMCID: PMC12895930

Genes

BRCA1
BDNF
BRCA2
RAD51
RAD51B
XRCC4
XRCC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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