Article
A Comprehensive Analysis of Influence ERCC Polymorphisms Confer on the Development of Brain Tumors.
Molecular neurobiology - 1 May 2016
Geng Peiliang, Ou Juanjuan, Li Jianjun, Liao Yunmei, Wang Ning, Xie Ganfeng, Sa Rina, Liu Chen, Xiang Lisha, Liang Houjie
Abstract excerpt
Within DNA repair genes, there lie a number of single nucleotide polymorphisms that may impair protein function and attenuate DNA repair capability, resulting in genomic instability and individual predisposition to malignancies. The purpose of this study was to assess the previously reported inconsistent association of polymorphisms in ERCC1 (rs11615, rs3212986), ERCC2 (rs13181, rs1799793, rs238406), and ERCC5...