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Article

ASTWAS: modeling alternative polyadenylation and SNP effects in kernel-driven TWAS reveal novel genetic associations for complex traits.

Briefings in bioinformatics - 7 Jan 2026

Wang Yan, Wang Lei, Sheng Nan, Hong Jie, Liu Yunzhi, Wu Pengze, Wang XinFei, Zhang Shuyan, Cao Chen

Abstract excerpt

Alternative polyadenylation (APA) of $3^{\prime}$untranslated regions ($3^{\prime}$UTRs) is a pervasive mechanism that regulates mRNA stability, localization, and translational efficiency by generating isoforms with distinct $3^{\prime}$UTR lengths and regulatory element composition. Despite its critical role in fine-tuning gene expression, APA has been largely overlooked in transcriptome-wide association studies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41554047
DOI: 10.1093/bib/bbaf725
PMCID: PMC12814985

Genes

GABBR1
RGL2
TOP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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