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Structure, functions, and recent advances in the development of SIRT2 inhibitors

9 Sept 2023

Abstract excerpt

Silent information regulators (sirtuins) are highly evolutionarily conserved and participate in many biological processes in the human body. Unlike classical histone deacetylases, the biological activity of sirtuins depends on nicotinamide adenine dinucleotide (NAD+). Among the seven human sirtuins, sirtuin 2 (SIRT2) is one of the most studied and plays important roles in cell aging, energy metabolism, and genome...

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PMID: 41550784
DOI: 10.1016/j.pscia.2023.100010

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