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Article

microRNA let-7g suppresses PDGF-induced conversion of vascular smooth muscle cell into the synthetic phenotype.

Journal of cellular and molecular medicine - 1 Dec 2017

Wang Tzu-Ming, Chen Ku-Chung, Hsu Po-Yuan, Lin Hsiu-Fen, Wang Yung-Song, Chen Chien-Yuan, Liao Yi-Chu, Juo Suh-Hang H

Abstract excerpt

Platelet-derived growth factor (PDGF) can promote vascular smooth muscle cells (VSMCs) to switch from the quiescent contractile phenotype to synthetic phenotype, which contributes to atherosclerosis. We aimed to investigate the role of microRNA let-7g in phenotypic switching. Bioinformatics prediction was used to find let-7g target genes in the PDGF/mitogen-activated protein kinase kinase kinase 1...

Topics

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Becaplermin
Calponins
Kruppel-Like Factor 4
MAP Kinase Kinase Kinase 1
Mitogen-Activated Protein Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitogen-Activated Protein Kinase 3

Plaque, Atherosclerotic

Proto-Oncogene Proteins c-sis

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Open in PubMed Open full text

Identifiers

PMID: 28699690
DOI: 10.1111/jcmm.13269
PMCID: PMC5706591

Genes

KLF4
PDGFB
SRF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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