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Article

Single nucleotide polymorphisms in the bepirovirsen binding site have limited impact on treatment response in chronic hepatitis B.

Journal of hepatology - 1 May 2026

Bouquet Jerome, Speer Scott D, Koenig Alexander, Livingston Christine M, Savarese Michael, Lau Chi, Angelini Elise, Galwey Nicholas, Yates Phillip, Maynard Lauren, You Shihyun, Cremer Jennifer, Paff Melanie, Theodore Dickens, Elston Rob, Walker Jill

Abstract excerpt

BACKGROUND & AIMS: Single nucleotide polymorphisms (SNPs) in the HBV genome may impact the efficacy of novel drugs for chronic HBV infection. This analysis of the B-Clear study (NCT04449029) evaluated the frequency of baseline and treatment-emergent SNPs in the bepirovirsen binding site and their association with virological response. METHODS: HBV sequencing was attempted for all baseline samples collected from...

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Antiviral Agents
Binding Sites
IMPACT gene
Hepatitis B, Chronic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hepatitis B Surface Antigens

Hepatitis B virus

Polymorphism, Single Nucleotide

Treatment Outcome

Source

Identifiers

PMID: 41544767
DOI: 10.1016/j.jhep.2025.12.025

Genes

IMPACT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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