Article
Viral minority variants in the core promoter and precore region identified by deep sequencing are associated with response to peginterferon and adefovir in HBeAg negative chronic hepatitis B patients.
Antiviral research - 1 Sept 2017
Jansen Louis, Welkers Matthijs R A, van Dort Karel A, Takkenberg R Bart, Lopatin Uri, Zaaijer Hans L, de Jong Menno D, Reesink Hendrik W, Kootstra Neeltje A
Abstract excerpt
BACKGROUND AND AIM: Precore (PC) and basal core promoter (BCP) mutations are associated with responses to interferon-based treatment in HBeAg-positive chronic hepatitis B (CHB) patients. Here, we identify viral minority variants in these regions and assess association with response to peginterferon-alfa (Peg-IFN) and adefovir combination therapy. PATIENTS AND METHODS: Ultra-deep pyrosequencing analysis of the BCP...
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