Article
Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure.
Nature communications - 20 Oct 2021
Smith David A, Fernandez-Antunez Carlota, Magri Andrea, Bowden Rory, Chaturvedi Nimisha, Fellay Jacques, McLauchlan John, Foster Graham R, Irving William L, Simmonds Peter, Pedergnana Vincent, Ramirez Santseharay, Bukh Jens, Barnes Eleanor, Ansari M Azim
Abstract excerpt
Persistent hepatitis C virus (HCV) infection is a major cause of chronic liver disease, worldwide. With the development of direct-acting antivirals, treatment of chronically infected patients has become highly effective, although a subset of patients responds less well to therapy. Sofosbuvir is a common component of current de novo or salvage combination therapies, that targets the HCV NS5B polymerase. We use...
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