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Article

Signal peptide missense variant in cancer-brake gene CTLA4 and breast cancer outcomes.

Gene - 5 May 2020

Babteen Nouf Abubakr, Fawzy Manal S, Alelwani Walla, Alharbi Raed A, Alruwetei Abdulmohsen M, Toraih Eman A, Elshazli Rami M

Abstract excerpt

The cancer-brake gene CTLA4 has a vital function in suppressing the immune responses of activated T lymphocytes. Numerous reports explored the impact of various CTLA4 variants with the predisposition for malignancies but with unconvincing findings. Hence, this study is designed to assess the association of CTLA4 (c.49A>G, rs231775) variant with the outcome of breast carcinoma. A total of 272 participants (93 BC...

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Breast Neoplasms
Case-Control Studies
CTLA-4 Antigen
Egypt

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation, Missense

Polymorphism, Single Nucleotide

Protein Sorting Signals

Source

Identifiers

PMID: 32044407
DOI: 10.1016/j.gene.2020.144435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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