Article

Enrichment of somatic mutations in schizophrenia brain targets prenatally active transcription factor bindings sites

2022-02-24

Abstract excerpt

Schizophrenia (SCZ) is a complex neuropsychiatric disorder in which both germline genetic mutations and maternal factors, such as infection and immune activation, have been implicated, but how these two strikingly different mechanisms might converge on the same phenotype is unknown. During development, cells accumulate somatic, mosaic mutations in ways that can be shaped by the cellular environment or endogenous p...

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Literature Corpus work: 4a7f5664-d2ec-5a86-af8b-9d52b8dbaca0
DOI: 10.1101/2022.02.23.481681

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