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Mosaic Brain Aneuploidy in Mental Illnesses: An Association of Low-level post-zygotic Aneuploidy with Schizophrenia and Comorbid Psychiatric Disorders

17 Jul 2017

Abstract excerpt

BACKGROUND: Postzygotic chromosomal variation in neuronal cells is hypothesized to make a substantial contribution to the etiology and pathogenesis of neuropsychiatric disorders. However, the role of somatic genome instability and mosaic genome variations in common mental illnesses is a matter of conjecture. MATERIALS AND METHODS: To estimate the pathogenic burden of somatic chromosomal mutations, we determined...

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PMID: 29606903
DOI: 10.2174/1389202918666170717154340

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