Article
The Contribution of Mosaic Chromosomal Alterations to Schizophrenia.
Biological psychiatry - 15 Jan 2025
Chang Kaihui, Jian Xuemin, Wu Chuanhong, Gao Chengwen, Li Yafang, Chen Jianhua, Xue Baiqiang, Ding Yonghe, Peng Lixia, Wang Baokun, He Lin, Xu Yifeng, Li Changgui, Li Xingwang, Wang Zhuo, Zhao Xiangzhong, Pan Dun, Yang Qiangzhen, Zhou Juan, Zhu Zijia, Liu Ze, Xia Disong, Feng Guoyin, Zhang Qian, Wen Yanqin, Shi Yongyong, Li Zhiqiang
Abstract excerpt
BACKGROUND: Mosaic chromosomal alterations are implicated in neuropsychiatric disorders, but the contribution to schizophrenia (SCZ) risk for somatic copy number variations (sCNVs) emerging in early developmental stages has not been fully established. METHODS: We analyzed blood-derived genotype arrays from 9715 patients with SCZ and 28,822 control participants of Chinese descent using a computational tool (MoChA)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.