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Article

Microsatellite Phenotype as a Guide for Immunotherapy in Colorectal Cancer: Current Status and Future Perspectives.

Genes - 9 Jun 2026

Koustas Evangelos, Trifylli Eleni-Myrto, Oraiopoulos Vaios, Karamouzis Michalis V, Sarantis Panagiotis

Abstract excerpt

The therapeutic armamentarium for colorectal cancer (CRC) has been significantly expanded with the introduction of immunotherapy, particularly immune checkpoint inhibitors (ICIs). However, the response to immunotherapy is strongly dependent on microsatellite instability (MSI) status. Tumors with high MSI (MSI-H) and/or mismatch repair deficiency (dMMR) exhibit high tumor mutational burden (TMB), increased...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42353833
DOI: 10.3390/genes17060674
PMCID: PMC13299501

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