The roles of ABCB1/P-glycoprotein drug transporters in regulating gut microbes and inflammation: insights from animal models, old and new

Abstract excerpt

Commensal enteric bacteria have evolved systems that enable growth in the ecologic niche of the host gastrointestinal tract. Animals evolved parallel mechanisms to survive the constant exposure to bacteria and their metabolic by-products. We propose that drug transporters encompass a crucial system to managing the gut microbiome. Drug transporters are present in the apical surface of gut epithelia. They detoxify...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Child Nutrition and Water Access
• Share to Drug Transport and Resistance Mechanisms
• Share to Gut microbiota and health