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Article

Zebrafish abcb11b mutant reveals strategies to restore bile excretion impaired by bile salt export pump deficiency.

Hepatology (Baltimore, Md.) - 1 Apr 2018

Ellis Jillian L, Bove Kevin E, Schuetz Erin G, Leino Daniel, Valencia C Alexander, Schuetz John D, Miethke Alexander, Yin Chunyue

Abstract excerpt

Bile salt export pump (BSEP) adenosine triphosphate-binding cassette B11 (ABCB11) is a liver-specific ABC transporter that mediates canalicular bile salt excretion from hepatocytes. Human mutations in ABCB11 cause progressive familial intrahepatic cholestasis type 2. Although over 150 ABCB11 variants have been reported, our understanding of their biological consequences is limited by the lack of an experimental...

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Identifiers

PMID: 29091294
DOI: 10.1002/hep.29632
PMCID: PMC6480337

Genes

ABCB11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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