Article

Targeted CRISPR activation and knockout screenings identify novel drug transporters

2023-07-03

Abstract excerpt

Tissue-specific drug uptake has not been well studied, compared to the deeper understanding of drug resistance mediated by the cellular efflux system such as MDR1 proteins. It has been suggested that many drugs need active or defined transporters to pass the cell membrane. In contrast to efflux components that are induced after anti-cancer drugs reach the intracellular compartment, drug importers are required for...

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Literature Corpus work: 5944ba1e-8607-5e62-9f0b-45c7c298819b
DOI: 10.21203/rs.3.rs-3119383/v1

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