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Article

A Phenotype-Structured PDE Framework for Investigating the Role of Hypoxic Memory on Tumor Invasion under Cyclic Hypoxia.

Bulletin of mathematical biology - 14 Jan 2026

Sadhu Gopinath, Jain Paras, George Jason Thomas, Jolly Mohit Kumar

Abstract excerpt

Tumor growth and angiogenesis drive complex spatiotemporal variation in micro-environmental oxygen levels. Previous experimental studies have observed that cancer cells exposed to chronic hypoxia retained a phenotype characterized by enhanced migration and reduced proliferation, even after being shifted to normoxic conditions, a phenomenon which we refer to as hypoxic memory. However, because dynamic hypoxia and...

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Identifiers

PMID: 41533050
DOI: 10.1007/s11538-025-01591-2
PMCID: PMC12804273

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