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Simulating Heterogeneous Tumor Cell Populations

28 Dec 2016

Abstract excerpt

Certain tumor phenomena, like metabolic heterogeneity and local stable regions of chronic hypoxia, signify a tumor's resistance to therapy. Although recent research has shed light on the intracellular mechanisms of cancer metabolic reprogramming, little is known about how tumors become metabolically heterogeneous or chronically hypoxic, namely the initial conditions and spatiotemporal dynamics that drive these...

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PMID: 28030620
DOI: 10.1371/journal.pone.0168984

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