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CD49f Expression in CD4+ T Cells and CD4 + FoxP3+ Tregs Reveals Immune Dysregulation and Potential Diagnostic Value in Systemic Lupus Erythematosus.

Immunology - 1 May 2026

Chen Xiaoning, Lin Weijie, Shen Bing, Xiong Ziqi, Zong Zhiwei, Chen Jie, Yang Bohao, Luo Hanxi, Bahabayi Ayibaota, Liu Chen

Abstract excerpt

This study aimed to characterise the expression and functional heterogeneity of CD49f across CD4+ T cell subsets in human peripheral blood, and to investigate alterations in regulatory T cells (Tregs) and CD4+ T cells in patients with systemic lupus erythematosus (SLE), together with their clinical relevance. A total of 43 newly diagnosed, treatment-naïve SLE patients and 21 age- and sex-matched healthy controls...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41532958
DOI: 10.1111/imm.70106

Genes

CD4
CD226
GZMB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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