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CD49a Expression Defines Tissue-Resident CD8 + T Cells Poised for Cytotoxic Function in Human Skin

1 Feb 2017

Abstract excerpt

Tissue-resident memory T (Trm) cells form a heterogeneous population that provides localized protection against pathogens. Here, we identify CD49a as a marker that differentiates CD8 + Trm cells on a compartmental and functional basis. In human skin epithelia, CD8 + CD49a + Trm cells produced interferon-γ, whereas CD8 + CD49a − Trm cells produced interleukin-17 (IL-17). In addition, CD8 + CD49a + Trm cells from...

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PMID: 28214226
DOI: 10.1016/j.immuni.2017.01.009

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