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Assessment of the Genetic Relationship Between Circulating Cytokines and Calcific Aortic Valvular Stenosis Using a Bidirectional Mendelian Randomization Analysis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 31 Jan 2026

He Junyi, Chen Boao, Mao Junling, Xia Ni, Zha Lingfeng

Abstract excerpt

Available studies have found associations between several cytokines and calcific aortic valvular stenosis (CAVS). To better comprehend the causal link between circulating cytokines and CAVS, we performed a bidirectional Mendelian randomization (MR) study. Genetic variants associated with 41 cytokines were obtained from public genome-wide association study (GWAS), and summary statistics for GWAS of CAVS were...

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PMID: 41532257
DOI: 10.1096/fj.202502613R

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