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Article

Deciphering the role of CX3CL1-CX3CR1 in aortic aneurysm pathogenesis: insights from Mendelian randomization and transcriptomic analyses.

Frontiers in immunology - 1 Jan 2024

Qian Xingyu, Zheng Yidan, Xu Li, Liu Zongtao, Chen Ming, Tong Fuqiang, Fan Pengning, Chen Zhe, Dong Nianguo, Zhang Chao, Liu Junwei

Abstract excerpt

Background: The crucial role of inflammation in aortic aneurysm (AA) is gaining prominence, while there is still a lack of key cytokines or targets for effective clinical translation. Methods: Mendelian randomization (MR) analysis was performed to identify the causal relationship between 91 circulating inflammatory proteins and AA and between 731 immune traits and AA. Bulk RNA sequencing data was utilized to...

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Share to Aortic Aneurysm
Share to Aortic aneurysm repair treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CX3C Chemokine Receptor 1

Share to Gene Expression Profiling

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Source

Open in PubMed Open full text

Identifiers

PMID: 38715600
DOI: 10.3389/fimmu.2024.1383607
PMCID: PMC11074460

Genes

CX3CR1
CX3CL1
FGF5
IL20RA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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