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Article

A phenome-wide bidirectional Mendelian randomization analysis of atrial fibrillation.

International journal of epidemiology - 10 Aug 2022

Wang Qin, Richardson Tom G, Sanderson Eleanor, Tudball Matthew J, Ala-Korpela Mika, Davey Smith George, Holmes Michael V

Abstract excerpt

BACKGROUND: The prevalence of atrial fibrillation (AF) is increasing with an aging worldwide population, yet a comprehensive understanding of its causes and consequences remains limited. We aim to assess the causes and consequences of AF via a bidirectional Mendelian randomization (MR) analysis. METHODS: We used publicly available genome-wide association study (GWAS) summary data, centralized and harmonized by an...

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Identifiers

PMID: 35292824
DOI: 10.1093/ije/dyac041
PMCID: PMC9365635

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