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Article

Small Nucleotide Variant Analysis Using RNA Fusion Panel (SMURF): Making the Most of RNAseq Data in Solid Tumours.

Journal of clinical laboratory analysis - 1 Feb 2026

Dorwal Pranav, Robin Julie, Krause Broden, Pyrchla Patricia, Yuan Bin, Quach Robert, Goh Anna Fong Na, Htain Pamela, Djitro Noel, Kumar Amit, Song Liyan, Siswara Priscillia, Svobodova Suzanne, Kaub Peter, Kumar Beena

Abstract excerpt

BACKGROUND: RNA-based fusion panels using targeted next-generation sequencing of formalin-fixed paraffin-embedded tumour tissue specimens are used for various tumour types to detect rearrangements/fusions. Using bioinformatic approaches, the data obtained from RNA sequencing (RNA-Seq) can also be used for small nucleotide variants analysis (single nucleotide variants and indels). METHODS: The performance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41531020
DOI: 10.1002/jcla.70164
PMCID: PMC12951097

Genes

CTNNB1
GNAQ
GNAS
NRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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