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TSG-6 Activated MSC-derived Extracellular Vesicles Present Altered micro-RNA Contents and Ameliorate the Inflammatory Phenotype of Macrophages in Vitro.

Inflammation - 13 Jan 2026

Martinez-Zalbidea Iker, Rzasa Alyssa, Puvanesarajah Varun, Hitzl Wolfgang, Wuertz-Kozak Karin

Abstract excerpt

Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have shown promising immunomodulatory properties; however, strategies to enhance their therapeutic potential remain limited. Here, we employed CRISPR activation of the gene TSG-6 in MSCs to evaluate the impact of elevated TSG-6 on EV cargo and immunomodulatory function in an in vitro macrophage model. CRISPR-mediated gene activation was confirmed by...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41526541
DOI: 10.1007/s10753-025-02398-y
PMCID: PMC12862027

Genes

MSC
CCL2
TNF
CXCL1
CXCL10
MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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