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Article

Dual-mode temperature-switchable TSCP probes for precise analysis of PIK3CA mutations and VAF.

Analytica chimica acta - 1 Feb 2026

Wu Xueqiang, Pu Xuyang, Xiong Nating, Rao Hui, Zhang Yinmei, Xu Tai

Abstract excerpt

BACKGROUND: Precision oncology requires robust methods for simultaneous mutation detection and variant allele frequency (VAF) quantification to guide therapeutic decisions. Current technologies face limitations in sensitivity, cost, and workflow complexity, particularly for assessing tumor heterogeneity. The development of dual-mode temperature-switchable TSCP probes addresses these challenges through an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41526121
DOI: 10.1016/j.aca.2025.345010

Genes

PIK3CA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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