Article
Multi-ancestry genome-wide association study and meta-analysis of lung function decline.
Respiratory research - 28 Feb 2026
Patchen Bonnie K, Zhang Jingwen, Gaddis Nathan, Bartz Traci M, Chen Jing, Debban Catherine, Leonard Hampton, Nguyen Ngoc Quynh H, Seo Jungkyun, Tern Courtney, Allen Richard, DeMeo Dawn L, Fornage Myriam, Melbourne Carl, Minto Melyssa, Moll Matthew, O'Connor George T, Pottinger Tess, Psaty Bruce M, Rich Stephen S, Rotter Jerome I, Silverman Edwin K, Stratford Jeran, Zhang Chengyue, Barr R Graham, Cho Michael H, Gharib Sina A, Manichaikul Ani, North Kari, Oelsner Elizabeth C, Simonsick Eleanor M, Tobin Martin D, Yu Bing, Choi Seung Hoan, Dupuis Josée, Cassano Patricia A, Hancock Dana B
Abstract excerpt
BACKGROUND: Despite evidence for a genetic component, few genetic associations with lung function decline have been identified. We aimed to evaluate genome-wide associations and putative downstream functionality of genetic variants for lung function decline. METHODS: We conducted genome-wide association study (GWAS) analyses of decline in FEV1, FVC, and FEV1/FVC in 52,056 White (N = 44,988), Black (N = 5,788),...
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