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Article

SMC6 expression & outcome of breast cancer.

The Indian journal of medical research - 1 Nov 2025

Mangone Flavia Regina Rotea, Krepischi Ana Cristina Victorino, Pavanelli Ana Carolina, Gatti Pedro Henrique Fernandes, Carraro Dirce Maria, Nagai Maria A

Abstract excerpt

Background & objectives Genetic instability is frequent in tumour cells and might occur due to an imbalance of homologous recombination (HR). HR is a crucial mechanism of DNA double-strand break (DSB) repair that depends on the formation and resolution of Holliday junctions for genomic stability maintenance. The SMC6 complex with SMC5 is involved in DSB repair. We sought to investigate the association between...

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Source

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Identifiers

PMID: 41520270
DOI: 10.25259/IJMR_881_2025
PMCID: PMC12826375

Genes

SMC6
BRCA1
BRCA2
SMC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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