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Article

Theoretical Insights into Mutation and Histidine Tautomerism Effects on Tau Proteins.

ACS chemical neuroscience - 17 Nov 2021

Li Hao, Joo Eunjung, Lee Jin Yong

Abstract excerpt

Research on misfolding of tau proteins will help to better understand the formation process of neurofibrillary tangles, a hallmark of Alzheimer's disease. Mutation and histidine tautomeric effects have been considered the two most important inherent factors for tau protein misfolding. In current research, replica-exchange molecular dynamics (REMD) were performed to characterize the structural properties of the...

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PMID: 34735109
DOI: 10.1021/acschemneuro.1c00594

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