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Article

Tumor plasticity and therapeutic resistance in oncogene-addicted non-small cell lung cancer: from preclinical observations to clinical implications.

Critical reviews in oncology/hematology - 1 Apr 2023

Toyokawa Gouji, Bersani Francesca, Bironzo Paolo, Picca Francesca, Tabbò Fabrizio, Haratake Naoki, Takenaka Tomoyoshi, Seto Takashi, Yoshizumi Tomoharu, Novello Silvia, Scagliotti Giorgio V, Taulli Riccardo

Abstract excerpt

The identification of actionable targets in oncogene-addicted non-small cell lung cancer (NSCLC) has fueled biomarker-directed strategies, especially in advanced stage disease. Despite the undeniable success of molecular targeted therapies, duration of clinical response is relatively short-lived. While extraordinary efforts have defined the complexity of tumor architecture and clonal evolution at the genetic...

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PMID: 36925092
DOI: 10.1016/j.critrevonc.2023.103966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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