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Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 23 Feb 2010

Conine Colin C, Batista Pedro J, Gu Weifeng, Claycomb Julie M, Chaves Daniel A, Shirayama Masaki, Mello Craig C

Abstract excerpt

Gametogenesis is a thermosensitive process in numerous metazoans, ranging from worms to man. In Caenorhabditis elegans, a variety of RNA-binding proteins that associate with germ-line nuage (P granules), including the Piwi-clade argonaute PRG-1, have been implicated in maintaining fertility at elevated temperature. Here we describe the role of two AGO-class paralogs, alg-3 (T22B3.2) and alg-4 (ZK757.3), in...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Fertility
Hot Temperature
Male
Mutation
RNA, Small Interfering
RNA-Binding Proteins
Spermatogenesis

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Identifiers

PMID: 20133686
DOI: 10.1073/pnas.0911685107
PMCID: PMC2840486

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Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans.PMID 20133686Read ↗

RNAi-mediated regulation of <i>alg-3</i> and <i>alg-4</i> coordinates the spermatogenesis developmental program in <i>C. elegans</i>Semantic proximity Read ↗

ALG-5 is a miRNA-associated Argonaute required for proper developmental timing in the Caenorhabditis elegans germline.Semantic proximity Read ↗

The microRNA pathway controls germ cell proliferation and differentiation in C. elegans.Semantic proximity Read ↗

Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility.Semantic proximity Read ↗

Maternal and zygotic gene regulatory effects of endogenous RNAi pathwaysSemantic proximity Read ↗

PUF-8 Functions Redundantly with GLD-1 to Promote the Meiotic Progression of Spermatocytes in Caenorhabditis elegans.Semantic proximity Read ↗

PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans.Semantic proximity Read ↗

Two isoforms of the essential <i>C. elegans</i> Argonaute CSR-1 differentially regulate sperm and oocyte fertilitySemantic proximity Read ↗

CSR-1 and P granules suppress sperm-specific transcription in the<i>C. elegans</i>germlineSemantic proximity Read ↗

Argonautes Promote Male Fertility and Provide a Paternal Memory of Germline Gene Expression in C. elegansSemantic proximity Read ↗

Optimal male fertility and fecundity in Caenorhabditis elegans require Microprocessor and Argonaute gene function.Semantic proximity Read ↗

PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans.Semantic proximity Read ↗

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