Article

CNS-selective plasma p-tau217 accurately captures Alzheimer’s disease pathology and progression

2026-05-21

Abstract excerpt

Blood-based biomarkers have expanded access to biologically supported diagnosis of Alzheimer’s disease (AD), particularly through measurement of amyloid-beta (Aβ) and phosphorylated tau species 1–3 . Among these, plasma tau phosphorylated at threonine 217 (p-tau217) is currently the leading biomarker recommended by clinical guidelines 4–6 . However, circulating p-tau217 originates from both central nervous syste...

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Literature Corpus work: 32a848e2-37e7-5d45-b48d-6cfb0129b50e
DOI: 10.64898/2026.05.18.26353208

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