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Article

Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders.

JAMA - 25 Aug 2020

Palmqvist Sebastian, Janelidze Shorena, Quiroz Yakeel T, Zetterberg Henrik, Lopera Francisco, Stomrud Erik, Su Yi, Chen Yinghua, Serrano Geidy E, Leuzy Antoine, Mattsson-Carlgren Niklas, Strandberg Olof, Smith Ruben, Villegas Andres, Sepulveda-Falla Diego, Chai Xiyun, Proctor Nicholas K, Beach Thomas G, Blennow Kaj, Dage Jeffrey L, Reiman Eric M, Hansson Oskar

Abstract excerpt

Importance: There are limitations in current diagnostic testing approaches for Alzheimer disease (AD). Objective: To examine plasma tau phosphorylated at threonine 217 (P-tau217) as a diagnostic biomarker for AD. Design, Setting, and Participants: Three cross-sectional cohorts: an Arizona-based neuropathology cohort (cohort 1), including 34 participants with AD and 47 without AD (dates of enrollment, May...

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Identifiers

PMID: 32722745
DOI: 10.1001/jama.2020.12134
PMCID: PMC7388060

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