Plasma p-tau231 in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional and longitudinal cohort study.

doi:10.1002/alz.70421

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Article

Plasma p-tau231 in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional and longitudinal cohort study.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2025

Malotaux Vincent, Ashton Nicholas J, Öhrfelt Annika, Chen Yinghua, Su Yi, Garcia-Ospina Gloria, Guzman-Martínez Claudia, Villegas-Lanau Andres, Gómez-Ramirez Johana, Giraldo-Chica Margarita, Aguillon David, Tirado Victoria, Baena Ana, Munoz Claudia, Acosta-Baena Natalia, Pruzin Jeremy J, Ghisays Valentina, Rios-Romenets Silvia, Vila-Castelar Clara, Martínez Jairo E, Giudicessi Averi, Tariot Pierre N, Zetterberg Henrik, Blennow Kaj, Reiman Eric M, Quiroz Yakeel T

Abstract excerpt

INTRODUCTION: Plasma phosphorylated tau (p-tau)-231 is a promising biomarker for Alzheimer's disease (AD), particularly in preclinical stages. We evaluated its diagnostic value in presenilin 1 (PSEN1) E280A mutation carriers versus non-carriers and compared it to p-tau217 and neurofilament light chain (NfL). METHODS: We analyzed plasma p-tau231 in 722 carriers and 640 non-carriers (ages 18-75). Longitudinal data...

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PMID: 40588692
DOI: 10.1002/alz.70421
PMCID: PMC12208796

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PSEN1

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