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Article

Quantitation of the latent HIV-1 reservoir from the sequence diversity in viral outgrowth assays.

Retrovirology - 5 Jul 2018

Poon Art F Y, Prodger Jessica L, Lynch Briana A, Lai Jun, Reynolds Steven J, Kasule Jingo, Capoferri Adam A, Lamers Susanna L, Rodriguez Christopher W, Bruno Daniel, Porcella Stephen F, Martens Craig, Quinn Thomas C, Redd Andrew D

Abstract excerpt

BACKGROUND: The ability of HIV-1 to integrate into the genomes of quiescent host immune cells, establishing a long-lived latent viral reservoir (LVR), is the primary obstacle to curing these infections. Quantitative viral outgrowth assays (QVOAs) are the gold standard for estimating the size of the replication-competent HIV-1 LVR, measured by the number of infectious units per million (IUPM) cells. QVOAs are...

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Identifiers

PMID: 29976219
DOI: 10.1186/s12977-018-0426-1
PMCID: PMC6034329

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