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Article

Influence of affinity and antigen internalization on the uptake and penetration of Anti-HER2 antibodies in solid tumors.

Cancer research - 15 Mar 2011

Rudnick Stephen I, Lou Jianlong, Shaller Calvin C, Tang Yong, Klein-Szanto Andres J P, Weiner Louis M, Marks James D, Adams Gregory P

Abstract excerpt

Antibody drugs are widely used in cancer therapy, but conditions to maximize tumor penetration and efficacy have yet to be fully elucidated. In this study, we investigated the impact of antibody binding affinity on tumor targeting and penetration with affinity variants that recognize the same epitope. Specifically, we compared four derivatives of the C6.5 monoclonal antibody (mAb), which recognizes the same HER2...

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Identifiers

PMID: 21406401
DOI: 10.1158/0008-5472.CAN-10-2277
PMCID: PMC3077882

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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