Association of the rs17822931 (538G > A, G180R) in the ABCC11 gene with risk of middle ear cholesteatoma in older adults: a hospital-based case-control study at Heidelberg University Hospital, Germany.

doi:10.1007/s00405-025-09933-5

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Association of the rs17822931 (538G > A, G180R) in the ABCC11 gene with risk of middle ear cholesteatoma in older adults: a hospital-based case-control study at Heidelberg University Hospital, Germany.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery - 1 Apr 2026

Nakagawa Hiroshi, Imai Ritsuko, Gestewitz Martin, Praetorius Mark, Tsukamoto Megumi, Albrecht Tobias, Kusunoki Takeshi, Ikeda Katsuhisa, Sertel Serkan

Abstract excerpt

BACKGROUND: Cholesteatoma is a progressive disease characterized by abnormal proliferation of keratinizing squamous epithelium within the temporal bone. Although both congenital and acquired forms have been recognized, the molecular mechanisms underlying its development remain poorly understood. Although surgery is the only curative option, the high recurrence rates underscore the need to identify genetic risk...

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PMID: 41495507
DOI: 10.1007/s00405-025-09933-5

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ABCC11

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