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Article

Impact of Reduced Acidic Earwax pH and Earwax-Determinant Genotypes in Acquired Middle Ear Cholesteatoma.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 1 Nov 2024

Hara Satoshi, Kusunoki Takeshi, Nakagawa Hiroshi, Kamiya Kazusaku, Toyoda Yu, Takata Yusuke, Anzai Takashi, Furukawa Masayuki, Okada Hiroko, Nakayama Takumi, Ikeda Katsuhisa, Matsumoto Fumihiko

Abstract excerpt

OBJECTIVE: The development of acquired middle ear cholesteatoma is associated with a single nucleotide polymorphism, 538G>A, in the human adenosine triphosphate-binding cassette transporter C11 (ABCC11) gene, which is a determinant of the earwax morphotype, such as wet- and dry-type earwax; however, the mechanism underlying this association is unclear. We focused on the earwax pH and aimed to elucidate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38953179
DOI: 10.1002/ohn.888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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