Article
Association of the GABRB3 gene with nonsyndromic oral clefts.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association - 1 May 2008
Inoue Hiroki, Kayano Shuji, Aoki Yoko, Kure Shigeo, Yamada Atsushi, Hata Akira, Matsubara Yoichi, Suzuki Yoichi
Abstract excerpt
OBJECTIVE: Nonsyndromic oral clefts are common craniofacial anomalies classified into two subgroups: cleft lip with or without cleft palate and isolated cleft palate. Nonsyndromic oral clefts are multifactorial diseases, with both genetic and environmental factors involved in their pathogenesis. The inhibitory neurotransmitter, gamma-aminobutyric acid plays a role in normal embryonic, and particularly facial,...
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