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Article

Are human ATP-binding cassette transporter C11 and earwax associated with the incidence of cholesteatoma?

Medical hypotheses - 1 May 2018

Nakagawa Hiroshi, Toyoda Yu, Albrecht Tobias, Tsukamoto Megumi, Praetorius Mark, Ishikawa Toshihisa, Kamiya Kazusaku, Kusunoki Takeshi, Ikeda Katsuhisa, Sertel Serkan

Abstract excerpt

Cholesteatoma is an ear disease based on a locally destructive noncancerous conglomerate of epidermis and keratin debris. Abnormal growth of stratified keratinized squamous epithelium in the temporal bone causes destruction of the outer and middle ear, potentially leading to hearing impairment, facial palsy, vertigo, lateral sinus thrombosis, and intracranial complications. Although cholesteatoma is effectively...

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Source

Identifiers

PMID: 29602456
DOI: 10.1016/j.mehy.2018.02.030

Genes

ABCC11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Are human ATP-binding cassette transporter C11 and earwax associated with the incidence of cholesteatoma?PMID 29602456Read ↗

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Impact of Reduced Acidic Earwax pH and Earwax-Determinant Genotypes in Acquired Middle Ear Cholesteatoma.Semantic proximity Read ↗

Association of the rs17822931 (538G > A, G180R) in the ABCC11 gene with risk of middle ear cholesteatoma in older adults: a hospital-based case-control study at Heidelberg University Hospital, Germany.Semantic proximity Read ↗

A SNP in the ABCC11 gene is the determinant of human earwax type.Semantic proximity Read ↗

A Novel Association between the 27-bp Deletion and 538G>A Mutation in the ABCC11 Gene.Semantic proximity Read ↗

Association of CARD8 Activating Polymorphism With Bone Erosion in Cholesteatoma Patients.Semantic proximity Read ↗

Association between breast cancer risk and the wild-type allele of human ABC transporter ABCC11.Semantic proximity Read ↗

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Allele frequencies of a SNP and a 27-bp deletion that are the determinant of earwax type in the ABCC11 gene.Semantic proximity Read ↗

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