Article
Association of alpha B-crystallin genotypes with oral cancer susceptibility, survival, and recurrence in Taiwan.
PloS one - 1 Jan 2011
Bau Da-Tian, Tsai Chia-Wen, Lin Cheng-Chieh, Tsai Ru-Yin, Tsai Ming-Hsui
Abstract excerpt
BACKGROUND: Alpha B-crystallin (CRYAB) is a protein that functions as "molecular chaperone" in preserving intracellular architecture and cell membrane. Also, CRYAB is highly antiapoptotic. Abnormal CRYAB expression is a prognostic biomarker for oral cancer, while its genomic variations and the association with carcinogenesis have never been studied. METHODOLOGY/FINDING: Therefore, we hypothesized that CRYAB...
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