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Article

Association Between Earwax-Determinant Genotypes and Acquired Middle Ear Cholesteatoma in a Japanese Population.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 1 Jan 2022

Hara Satoshi, Kusunoki Takeshi, Nakagawa Hiroshi, Toyoda Yu, Nojiri Shuko, Kamiya Kazusaku, Furukawa Masayuki, Takata Yusuke, Okada Hiroko, Anzai Takashi, Matsumoto Fumihiko, Ikeda Katsuhisa

Abstract excerpt

OBJECTIVE: A single-nucleotide polymorphism 538G>A in the human ABCC11 gene is a determinant of the earwax morphotype. ABCC11 538GG and GA correspond to wet earwax and 538AA to dry earwax. Despite a putative positive correlation between the frequency of the 538G allele and the prevalence of cholesteatoma, minimal clinical information is currently available. We aimed to evaluate this association between the ABCC11...

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PMID: 33722103
DOI: 10.1177/01945998211000374

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