Phylodynamics of Somatic Evolution: A Likelihood-Based Approach for Cellular Reproduction.

Abstract excerpt

Understanding the evolutionary dynamics of cell populations requires models that link observed phylogenetic patterns to the underlying processes of cell division, death, and mutation. Classical phylodynamic inference methods-developed primarily for macroevolutionary settings-assume that mutations accrue in calendar time and often rely on a molecular clock. Here, we introduce a framework that ties mutations to...

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