H195Y mutation of IKZF3 identified in a mouse model of precursor B cell acute lymphoblastic leukemia impairs transcriptional repression activity and increases protein stability.

Abstract excerpt

IKZF3/Aiolos is a zinc-finger transcriptional transcription factor that functions as a transcriptional repressor in B cell development. IKZF3 mutations are associated with human diseases including immunodeficiency, leukemia, and lymphoma. H195Y IKZF3 mutation was discovered in a mouse model of precursor B cell acute lymphoblastic leukemia. Forced expression of H195Y IKZF3 in precursor B (pre-B) cells altered gene...

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