Article
IKZF3/Aiolos H195Y mutation identified in a mouse model of B cell leukemia results in altered DNA binding and altered STAT5-dependent gene expression.
Gene - 30 Mar 2024
Rodrigues de Oliveira Bruno, Iansavitchous James, Rysan Heidi, Wang Wei Cen, Sams Mia P, Knight Devon, Xu Li S, Jeong Jeewoo, Qu Thomas P, Zorzi Alexandra P, DeKoter Rodney P
Abstract excerpt
Precursor B cell acute lymphoblastic leukemia (Pre-B-ALL) arises from developing B cells and frequently involves mutations in genes encoding transcription factors. In this study, we investigated the function of mutations in the transcription factor IKZF3 (Aiolos), R137* and H195Y, discovered in a mouse model of pre-B-ALL. R137* IKZF3 mutation resulted in a truncated protein, while electrophoretic mobility shift...
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