The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment.

doi:10.1158/2326-6066.CIR-20-0527

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Article

The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment.

Cancer immunology research - 1 Jan 2021

Väyrynen Juha P, Haruki Koichiro, Lau Mai Chan, Väyrynen Sara A, Zhong Rong, Dias Costa Andressa, Borowsky Jennifer, Zhao Melissa, Fujiyoshi Kenji, Arima Kota, Twombly Tyler S, Kishikawa Junko, Gu Simeng, Aminmozaffari Saina, Shi Shanshan, Baba Yoshifumi, Akimoto Naohiko, Ugai Tomotaka, Da Silva Annacarolina, Guerriero Jennifer L, Song Mingyang, Wu Kana, Chan Andrew T, Nishihara Reiko, Fuchs Charles S, Meyerhardt Jeffrey A, Giannakis Marios, Ogino Shuji, Nowak Jonathan A

Abstract excerpt

Macrophages are among the most common cells in the colorectal cancer microenvironment, but their prognostic significance is incompletely understood. Using multiplexed immunofluorescence for CD68, CD86, IRF5, MAF, MRC1 (CD206), and KRT (cytokeratins) combined with digital image analysis and machine learning, we assessed the polarization spectrum of tumor-associated macrophages in 931 colorectal carcinomas. We then...

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PMID: 33023967
DOI: 10.1158/2326-6066.CIR-20-0527
PMCID: PMC7785652

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